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Exercise And Colon Cancer Treatment

November 21, 2019


This study is looking at how exercise may prevent the recurrence of colon cancer in patients who have completed their treatment. The primary objective is to determine if aerobic exercise can reduce systemic inflammation.  The secondary objectives are to determine if exercise can reduce: 1) insulin resistance 2) circulating tumor cells. Another, exploratory objective is to determine if exercise can improve mitochondrial respiration rates and fatty acid oxidation.


Study Information

This trial will involve an estimated 60 subjects who have completed standard treatment for colon cancer. Some of the participants will partake in 12-weeks of moderate-intensity aerobic exercise, and the others will maintain their pre-study levels of physical activity. The study began on August 16th 2019 and is estimated to be completed on July 21st 2022.


Inclusion Criteria


  • Over 18 years old
  • Confirmed stage III colon cancer
  • Completed surgical resection within 1-24 months
  • Completed chemotherapy (if applicable) within 1-24 months
  • Self-report, on average over the past one-month, less than or 90 minutes per week of moderate-intensity or vigorous-intensity physical activity
  • Provide written approval by physician or other qualified healthcare provider
  • No planned major surgery during the study period (including colostomy reversal; chemotherapy infusion port removal is permitted)
  • Readiness to exercise [as determined by a modified version the Physical
  • Activity Readiness Questionnaire (PAR-Q)
  • Allow the collection and storage of specimens and data for future use 1.10
  • Willing to be randomized


Exclusion Criteria


  • Evidence of metastatic colon cancer
  • Concurrently actively treated other cancer (except non-melanoma skin cancer or in situ cancers)
  • Currently enrolled in another clinical trial of weight loss, physical activity, or dietary intervention
  • Current body mass greater than or equal to 181 kg
  • Unable to provide a baseline fasting blood sample
  • Unable or unwilling to give informed consent
  • Unable or unwilling to be randomized
  • Or any other condition that may impede testing of the study hypothesis or make it unsafe to engage in the exercise program (as determined by the investigative team)



You may participate in this study at Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States, 70808. For further information, please contact Kaylee T. Woodard at



This study is sponsored by Pennington Biomedical Research Center and the National Cancer Institute (NCI). The Principal Investigator is Justin C Brown, Ph.D. of the Pennington Biomedical Center.

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