In addition to chemotherapy for stage four colon cancer, recently, there has been some research that has shown the effectiveness of immune therapy in a subset of patients with colon cancer who have a certain mutation. So if these mutations are found in the tumor cells, based on studies that are done after surgery or biopsy, we know that those patients can actually benefit from chemotherapy for their stage four colon cancer, which is a very exciting new development and a great new option for these patients who will not have had this option in the past and often would have had no option after a recurring from their treatment or becoming resistant to the chemotherapy.